S. Curet, M. Mazen Hamoud-Agha
GEPEA, UMR 6144, CNRS, ONIRIS, Université de Nantes, Nantes, France
In this study, COMSOL®4.2a is used to model a microwave heating process in a TE10 rectangular waveguide. The sample consists of a small cylindrical Ca-alginate gel (D = 8 mm, H = 10 mm) inoculated with bacteria Escherichia Coli K12. The sample is placed along the microwave propagation direction into the waveguide. Maxwell’s equations and heat transfer are coupled to a microbial inactivation ...
A Multiscale-Multiphysics Model for Axon Pathfinding Simulation, the Example of the Olfactory System
G. Naldi, G. Aletti, P. Causin
Dipartimento di Matematica ‘F. Enriques’, Università degli Studi di Milano, Milano, Italy
In the developing embryo, neurons form connections by projecting axons to appropriate target areas. The projection process includes neurite elongation, resulting from the assembly of new cytoskeletal material at the free end of the axon, a complex cascade of steering decisions, driven by biomechanical properties of the surrounding environment and by signals in it. In this work we focus on the ...
I.M. Abdel-Motaleb, J. Lavrencik 
Department of Electrical Engineering, Northern Illinois University, DeKalb, IL, USA
There is urgent need to monitor dental and oral diseases, such as tooth decay, gum diseases, and teeth grinding. Such monitoring can be achieved by embedding sensors in the mouth. This technique faces some difficulties. The first is how the power needed for the operation of the sensors and the associated electronic chips can be generated. This power can be generated using the pressure exerted by ...
J. Ferdous, M. Ghaly , V. B. Kolachalama , T. Shazly[1,4]
Biomedical Engineering Program, University of South Carolina, Columbia, SC, USA
Department of Biomedical Engineering, North Carolina State University, Raleigh, NC, USA
Charles Stark Draper Laboratory, Cambridge, MA, USA
Department of Mechanical Engineering, University of South Carolina, Columbia, SC, USA
Inferior vena cava (IVC) filters have become essential components in deep vein thrombosis treatment to prevent preventing pulmonary embolisms. Filter efficacy relies on maintaining IVC patency by preventing filter-induced thrombosis following clot capture. A computational model has been developed to determine whether a candidate filter design elicits hemodynamic patterns that promote thrombus ...
U. Topaloglu, Y. Yan, P. Novak, P. Spring, J. Suen, and G. Shafirstein
 Department of Information Technology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Department of Otolaryngology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Thermal ablation in the head and neck requires accurate thermal dose delivery to target tissue while protecting the structure and function of nearby tissue and organs. In this study, we present a method that allows importing Computed Tomography (CT) scans to COMSOL, in order to model accurately the expected pathological outcomes prior to thermal ablation treatment. Thermal ablation of a virtual ...
D. Iber, D. Menshykau, and P. Germann
Department of Biosystems Science and Engineering
Organogenesis is a tightly regulated process that has been studied experimentally for decades. Computational models can help to integrate available knowledge and to better understand the underlying regulatory logic. We are currently studying mechanistic models for the development of limbs, lungs, kidneys, and bone. We have tested a number of alternative methods to solve our spatio-temporal ...
Lowering of the Interstitial Fluid Pressure as a Result of Tissue Compliance Changes during High Intensity Focused Ultrasound Exposure: Insights from a Numerical Model
E. Sassaroli, B. O'Neill 
The Methodist Hospital Research Institute, Houston, TX, USA
Interstitial fluid pressure (IFP) is elevated in tumors. Owing to this elevated IFP, the interstitial fluid velocity (IFV) is negligible throughout the tumor but significant near the tumor margin. Any therapeutic strategy that can lower IFP will improve drug convection within the tumor and decrease convection of drugs from the tumor margin. High intensity focused ultrasound (HIFU) has been shown ...
Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA
We are developing approximations of electrically anisotropic materials for use in novel imaging methods. Our modeling work in COMSOL comprises comparisons of anisotropic and layered models in terms of electrical conductivities measured using different strategies. We tested solution stability in one anisotropic case by varying mesh anisotropy. In our case, good approximations to the true ...
E. P. Furlani, N. M. Litchinitse, and R. Biswas
The Institute for Lasers, Photonics and Biophotonics, University at Buffalo, Buffalo, New York, USA
Department of Electrical Engineering, The State University of New York at Buffalo,Buffalo, New York, USA
We present a study of an optofluidic biosensor. The sensor operates in a transmission mode wherein detection is based on a shift in the transmission spectrum caused by the contrast in refractive index between the carrier fluid and the target biomaterial. We study the behavior of the sensor using 2D full-wave electromagnetic analysis, and perform parametric studies of sensitivity as a function ...
An Efficient Finite Element Analysis on an RF Structure Used to Evaluate the Effect of Microwave Radiation on Uveal Melanoma Cells
A. Dulipovici, D. Roman, I. Stiharu, and V. Nerguizian
École de technologie supérieure, Montreal, Quebec, Canada
Concordia University, Montreal, Quebec, Canada
The use of Microwave/RF energy on cancer cells is explored for tumor ablation using medium power level ranging between a few Watts to about 50 Watts. In this research, low power levels, less than 100 mWatt, are used to evaluate the effect of this energy on Uveal melanoma cells by proliferation tests. The COMSOL simulation of the RF structure used to evaluate the radiation energy on ...