Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Theoretical and Experimental Validation of Micro Hot Embossing on Polymeric Substrates

F. Lai [1], N. K. Shivaprakash [1], J. Zhang [1], A. Panwar [1], J. Mead [1], C. Barry [1], Q. Truong [2],
[1] University of Massachusetts Lowell, Lowell, MA, USA
[2] US Army Natick Soldier Research, Development and Engineering Center, Natick, MA, USA

Micro hot embossing on a large area polymeric substrates using roll-to-roll (R2R) mode has been considered as one of the most promising technologies that can offer continuous fabrication of large area polymeric substrates. Besides continuous operation, roll-to-roll (R2R) process offers advantages such as low forming load and higher replication accuracy. Consequently, R2R embossed polymeric ...

An Efficient Finite Element Analysis on an RF Structure Used to Evaluate the Effect of Microwave Radiation on Uveal Melanoma Cells

A. Dulipovici[1], D. Roman[2], I. Stiharu[2], and V. Nerguizian[1]

[1]École de technologie supérieure, Montreal, Quebec, Canada
[2]Concordia University, Montreal, Quebec, Canada

The use of Microwave/RF energy on cancer cells is explored for tumor ablation using medium power level ranging between a few Watts to about 50 Watts. In this research, low power levels, less than 100 mWatt, are used to evaluate the effect of this energy on Uveal melanoma cells by proliferation tests. The COMSOL simulation of the RF structure used to evaluate the radiation energy on ...

Some Clinical and Computational Studies On Haemodynamics In Stenosed Artery

A. Chanda, A.R. Choudhury, G. Ray, K. Dasgupta, and D. Nag
Jadavpur University, Kolkata, West Bengal, India

Atherosclerosis in arteries is caused by the formation of stenosis : fatty depositions, on the artery wall. In current medicine, the practice is to observe the maximum percentage occlusion at any arbitrary cross-section and diagnose the patient on that basis, which might not always present the real picture due to non-uniformity of the stenosis thickness. The present work attempts to simulate the ...

Computationally Assisted Design and Experimental Validation of a Novel ‘Flow-Focussed’ Microfluidics Chip for Generating Monodisperse Microbubbles

M. Conneely[1], V. Hegde[2], H. Rolfsnes[1], A. Mason[2], D. McLean[1], C. Main[1], F.J.D. Smith[2], W.H.I. McLean[2], P.A. Campbell[1]
[1]Carnegie Physics Laboratory, University of Dundee, Dundee, Scotland, United Kingdom
[2]Division of Molecular Medicine, University of Dundee, Dundee, Scotland, United Kingdom

Whilst initially developed as a diagnostic aid to improve echogenicity in ultrasound imaging, gas-filled lipid microbubbles are now emerging as a next generation \'theranostic\' tool in the medical arena. Here, their therapeutic potential has now been realized through their unique capability to deliver molecular species such as drugs and genes by means of disrupting the cell membrane in response ...

Modeling of Silicon Piezoresistive Pressure Sensor: Application to Prevent Some Diabetes Complications

F. Kerrour[1], A. Beddiaf[1], M. Benabbas-Marir[1]
[1]MODerNa Laboratory, University Mentouri, Constantine, Algeria

Several analytical solutions describing the mechanical behavior of a silicon micro membrane deflection, perfectly embedded and subjected to a uniform and constant pressure have been proposed. The obtained results are compared with those obtained by using COMSOL software for a rectangular diaphragm deflection. COMSOL Multiphysics is powerful software for solving problems based on partial ...

Simulation of Normal and Cancerous T-cell Membrane Electroporation - new

O. Henao[1], V. Gómez[1], I. De la Pava[1], J. Sánchez[1]
[1]Grupo Fisiología Celular y Aplicada, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia

Electroporation is an increase of the cell membrane permeability due to the formation of aqueous pores in it when the cell is under the influence of an intense electric field [1][2]. The formation of such pores in the membrane can be used to enhance the uptake of chemotherapeutic drugs into the cell in a cancer treatment known as electrochemotherapy [3]. In some cases the direct experimental ...

Dried Reagent Resuspension for Point of Care Testing (Analysis at the Patient Bedside)

M. Huet [1],
[1] Department of Biotechnology, CEA/Université Grenoble-Alpes, Grenoble, France

A microfluidic component was designed to collect blood from a finger prick by capillary flow and to perform biological analysis. It was used to perform ABO blood typing experiments in one step, the blood drop deposit, by agglutination of red blood cells (RBC) using embedded dried reagents. The present study is a first step in the modeling of the whole agglutination assay. Blood typing ...

Optimal PDE Control Using COMSOL Multiphysics

I. Neitzel[1], U. Prüfert[2], and T. Slawig[3]

[1]Technische Universität Berlin / SPP 1253
[2]Technische Universität Berlin / Matheon
[3]Excellence Cluster The Future Ocean, Algorithmic Optimal Control - Oceanic CO2-Uptake/SPP 1253

An optimal control problem (OCP) is studied to a PDE of elliptic type as well as state constraints. The resulting optimality system contains two PDEs, one algebraic equation and the so called complementary slackness conditions, i.e. dual products between function spaces. At this point, different regularization techniques come into use. In this paper we introduce a Barrier method as one possible ...

Passive and Active Deformation Processes of 3D Fibre-Reinforced Caricatures of Cardiovascular Tissues

A. Di Carlo[1], P. Nardinocchi[2], T. Svaton[3], and L. Teresi[1]

[1]Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
[2]Dept. of Structural & Geotechnical Engineering, Università di Roma La Sapienza, Roma, Italy
[3]Dept. of Mathematics, University of West Bohemia, Pilsen, Czech Republic

In this paper, we present a mathematical model of contractile elastic solids meant to simulate various districts of the cardiovascular system, and based on the concepts of active deformation and embedded muscle fibres. Specifically, here we deal with the modeling of the gross mechanics of the Left Ventricle (LV) which is strictly related to its pump function. As is well known, the effectiveness ...

Shear Induced Detachment Of Microorganisms Attached To A Plane Wall

B. Boulbène, J. Morchain, and P. Schmitz
Université de Toulouse, NSA, UPS, INP, LISBP, Toulouse, France

We present numerical results involving microorganisms adhering to a plane surface submitted to a shear flow. The purpose is to have a better understanding of the removal mechanisms occurring during the cleaning in place of food processing equipments. The biological cell, i.e. the microorganism, is modelled as a rigid obstacle embedded in the bottom wall of the fluid domain. Shear induced ...