COMSOL Multiphysics® as a Tool for Reducing Animals in Biomedical Research: An Application in Dermatology
F. Rossi and R. Pini
Istituto di Fisica Applicata “Nello Carrara”, Consiglio Nazionale delle Ricerche, Firenze, Italy
In biomedical research the use of animal models gives rise to several ethical problems. COMSOL Multiphysics® may be used as a non-animal technique, very useful in overcoming all these concerns. In this presentation a particular application in dermatology is shown. Bioheat equation mode and diffusion approximation were used to design a theoretical model of blue LED light interaction with an ...
V. Valente, A. Demosthenous, and R. Bayford
Department of Electronic & Electrical Engineering, University College London, London, United Kingdom
Department of Natural Sciences, Middlesex University, London, United Kingdom
Deep Brain Stimulation (DBS) is a therapeutic tool used for a number of neurological disorders including chronic pain, incontinence and movement disorders, such as Parkinson’s disease. DBS consists of the low-frequency stimulation of an area of the brain, known as basal ganglia. The stimulation is provided by clinical implant, consisting of a pulse generator and an electrode lead ...
R. Winz, N. Schröder, W. Wiechert, and E. von Lieres
Institute of Biotechnology 2, Research Centre Jülich, Jülich, Germany
Research Center for Micro and Nanochemistry, University of Siegen, Siegen, Germany
In recent years lab-on-microchip technology has become a powerful tool for micro-scale analysis of biochemical processes. In the studied system the overall process consists of transport, convection, diffusion, reaction and adsorption processes. Two compounds A and B, contained in a carrier fluid (buffer), are introduced into a reaction channel via a Y-shaped double-inlet. As the streams flow ...
P. Alotto, M. Guarnieri, and F. Moro
Dipartimento di Ingegneria Elettrica, Università di Padova, Padova, Italy
The proton exchange membrane is a key component in the currently widely studied Proton Exchange Membrane Fuel Cells. In this paper a fully coupled three-dimensional dynamic numerical model of the membrane including all the physically relevant phenomena, i.e. ion transport, hydration-dependent conductivity and thermal effects is presented. The highly non-linear model is discretized by means of ...
Elastoplastic Models of the Interaction between Active Fronts of the Southern Alps and Dinarides (NE Italy and NW Slovenia)
M. Coccia, E. Carminati, F. Rolandone, M. Battaglia, D. Zuliani, and P. Fabris
Università La Sapienza, Roma, Italy
Université Pierre et Marie Curie, Paris, France
Centro Ricerche Sismologiche, Udine, Italy
We use GPS measurements and Finite Element analysis to investigate strain accumulation in the interaction between active fronts of the Southern Alps and Dinarides at the northern edge of the Adriatic micro-plate. We develop a three dimensional model of the area taking into account the regional topography, approximating the crust as an elasto-plastic medium and reproducing as close as possible ...
A. Schubert, R. Pohl, and M. Hackert
Chair Micromanufacturing Technology, Faculty of Mechanical Engineering, Chemnitz University of Technology, Chemnitz, Germany
Fraunhofer Institute for Machine Tools and Forming Technology, Chemnitz, Germany
Micro impact extrusion is investigated at Chemnitz University of Technology as a potential procedure for large area machining of micro cavities within the scope of the SFB/Transregio 39 PT-PIESA of the German Research Foundation. Applying impact extrusion micro forming is done by material flow opposite to the effective direction of the force into the structure of the tool. Therefore no ...
N. Diaz, A. Jakob, L. Van Loon, and D. Grolimund
Paul Sherrer Institut NES/LES, Villigen PSI, Switzerland
Paul Sherrer Institut NES/SLS, Villigen PSI, Switzerland
Opalinus clay is currently being proposed as a potential host rock for radioactive waste repository in deep geological formation. It is then important for performance assessments to understand the transport properties of such rocks. Clay materials are characterized by low hydraulic conductivities and diffusion is assumed to be the main transport mechanism. The studied rock is a complex assembly ...
R. Inglés, J. Pallares, J.L. Ramirez, and E. Llobet
Dept. of Electronic, Electrical and Automatic Control Engineering, Universitat Rovira i Virgili, Tarragona, Spain
Department of Mechanical Engineering School of Chemical
Engineering Universitat Rovira i Virgili, Tarragona, Spain
We use finite elements simulations in order to study the fluid flow behavior in a chamber of a preconcentrator. We realized that most part of the fluid does not affect our preconcentrator because it is going out the chamber at high distance above it and parallel to the preconcentrator. So, we are wasting most part of our fluid and we need a lot of time to have a good concentrator factor. We ...
A. Di Carlo, V. Sansalone, A. Tatone, and V. Varano
Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
Laboratoire de Mécanique Physique, Université Paris Est, Paris, France
DISAT, Università degli Studi dell’Aquila, L'Aquila, Italy
We present a mechanical model a growing spherical shell suitable for predicting the evolution of a Saccular Cerebral Artery Aneurysms (SCAA). It relies basically on the Kröner-Lee decomposition, used to describe the interplay between the current and the relaxed configuration of body elements. Rupture or stabilization of a SCAA are the end effect of a number of biological mechanisms, still poorly ...