COMSOL Day: Biomedical Applications
See what is possible with multiphysics simulation
Join fellow engineers and simulation specialists to learn about multiphysics simulations in applications that involve biomedical processes and devices.
We welcome both experienced COMSOL Multiphysics® users and those who are new to the COMSOL® software to attend COMSOL Day. The sessions will focus on modeling techniques in the respective application areas, and you will learn about the software features and best practices from applications engineers. Keynote speakers from industries based on or reliant on such devices will provide perspective on the importance of simulation to these applications.
Detailed schedule will follow soon. Register for free today and stay tuned!
Simulation helps experts and nonexperts alike better understand and optimize medical devices and biomedical processes. As a result, better implants, testing procedures, imaging devices, sensors, treatment methods, and much more have been developed faster and more efficiently as simulation has become more widespread.
However, significant bottlenecks have arisen and are often not dependent on the simulation software's ability to represent the complex and coupled physics prevalent in biomedical applications, but rather the limited number of skilled users who can create and run the desired models. For this reason, the trend is to make simulation possible for all involved in the development process to participate through the use and distribution of specialized simulation apps.
Biosensors exploit biological components in the detection of a chemical substance. For example, enzymes may be used to quantify contaminants, such as pesticides or antibiotics. In the medical and agrifood fields, antibodies may be used in biosensors to measure antigens. During an analysis, the ligand sees its modified properties and emits a physiochemical signal, which is transformed by a transducer into an analyzable signal.
In this presentation, we will discuss how the COMSOL Multiphysics® software can be used to model biosensor devices. We will demonstrate a model for the adsorption of antigens in aqueous solutions on an array of micropillars and examine the impact of design parameters, such as pillar diameter, grid spacing, and inlet velocity, on the detection capabilities.
Simulation apps enable you to expand your modeling and give more control to your colleagues who require simulations for their designs and processes. You can create user-specific modeling environments that are best suited to their simulation needs while also being easy enough for them to use, even if they are not modeling experts. During this Tech Café, you can discuss how best to develop simulation apps with COMSOL engineers, who will also be answering your specific questions.
Laurent Drazek, bioMérieux
The rise of COVID-19 has shown the importance of in vitro diagnostics (IVD) solutions for the monitoring and management of pandemics. In this context, a syndromic approach to diagnostic testing for infectious diseases has become increasingly pertinent and consequential. BioMérieux's BioFire FilmArray, a multiplex polymerase chain reaction (PCR) system for in vitro diagnostics, achieves this aim with a full respiratory panel, including SARS-CoV-2 and many other pathogens that cause symptoms common to COVID-19. BioFire FilmArray panels extend to many more syndromes, from gastrointestinal diseases to identification of pathogens in positive blood cultures. A careful optimization of several system parameters is required to achieve the desired sensitivity and specificity for each pathogen. For instance, given the vulnerability of PCR efficiency to small changes in temperature, thermal modeling can play an invaluable role in this process by providing a full, precise, and reliable thermal profile of the fluid containing the PCR reaction, as the fluid is otherwise inaccessible to traditional thermal measurement devices.
This presentation will show how FEM-based numerical simulations with COMSOL Multiphysics® can support the development and maintenance of highly sensitive systems dedicated to IVD.
Learn the fundamental workflow of COMSOL Multiphysics®. This introductory demonstration will show you all of the key modeling steps, including geometry creation, setting up physics, meshing, solving, and postprocessing.
Acoustics-based methods and devices play an important role in medical technology. Applications range from diagnostic and therapeutic ultrasound procedures to hearing aids. In this session, you will learn more about the possibilities and challenges that arise in such applications, such as nonlinearities and thermoviscous effects, which must be taken into account for realistic models, analyses, and to find optimized design parameters and operating conditions.
Learn and discuss how to model and simulate electromagnetic heating problems in biomaterials using the Heat Transfer Module, AC/DC Module, and RF Module within the COMSOL® software environment.
Thomas Clavet, EMC3 Consulting
Acoustic waves in the ultrasonic range are widely used in many industries, including MedTech. For instance, echography is a well-known medical imaging technique that is often prescribed to diagnose an illness or health issue.
In addition to diagnostics, ultrasound can also provide a noninvasive way to treat a condition. Focused ultrasound (FUS) devices have become a common choice to kill cancerous tumors in the prostate, breast, pancreas, liver, and brain, but other conditions also take advantage of focused ultrasound, such as neurodegenerative diseases and glaucoma. Research in the field is very important and could lead to disruptive technologies and novel treatments in years to come.
High-intensity focused ultrasound (HIFU) ablation tools are designed to produce a localized elevation of temperature and necrosis of biological tissues. Simulating the acoustics and heat transfer phenomena involved in such tools allows engineers and researchers to select the combination of parameters that will deliver the right amount of energy in the targeted zone and limit the damage to the surrounding healthy tissues. There are numerous parameters, including the size of the transducer that transmits the ultrasound, the frequency of the signal, and the duration of the treatment.
Challenges remain as well, related to the knowledge of acoustics and thermal properties of tissues, and the nonlinear effects that happen at these high frequencies and amplitudes. Thus, there is still a long way to go before having a patient-specific treatment planning simulator, but the COMSOL® software would be a solution of choice to try to reach this goal.
In this presentation, Thomas Clavet from EMC3 Consulting will discuss how HIFU can be produced and key points about how to model this multiphysics problem.
RF-based electromagnetic ablation, cardiac pacemakers, and magnetic resonance imaging systems are all examples of biomedical device applications that rely on electromagnetic interactions with biological tissue. Multiphysics simulation can help to better understand, develop, improve, and optimize these applications. In this session, you will learn how such applications can be set up and applied to real-life cases through the use of both predefined modeling interfaces and the ability to manipulate the underlying modeling strategies and parameters provided by these interfaces.
In order to learn more about the mechanical behavior of soft tissues by means of simulation, various aspects of the tissue have to be considered, which makes such applications very challenging from a modeling point of view. In addition to the nonlinear structural material behavior, which also often has anisotropic and heterogeneous parameters, the fluid–structure interactions between, for example, non-Newtonian blood and veins, are often critical.
In this Tech Café, you will be able to discuss these aspects of biomechanics simulation with COMSOL technical staff and ask them questions specific to your applications.
Technology Manager, Acoustics